Download Amyloid Proteins: The Beta Sheet Conformation and Disease by Jean D. Sipe PDF

By Jean D. Sipe

A first-stop reference on proteins linked to amyloidosis. This ebook is the 1st to offer a scientific assessment of all recognized fibril-forming proteins, together with their biochemical features and pathophysiology. It considers the clinically famous amyloid proteins which are identified to be linked to the amyloid protein folding issues, facing their universal structural and thermodynamic beneficial properties that bring about amyloid fibril formation and affliction. Emphasis is at the thermodynamics of protein folding, the constitution and physiologic results of universal oligomeric and subfibrillar intermediates and the impact of the extracellular matrix and mobile trafficking and metabolism at the genesis and catabolism of beta pleated sheet proteins. The chapters on particular amyloid proteins all persist with a typical constitution, permitting easy accessibility to the specified biochemical and scientific facts, making this a useful software for clinicians and researchers alike.

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Extra info for Amyloid Proteins: The Beta Sheet Conformation and Disease

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T. D. O’Brien, D. W. Hayden, K. Jordan, H. K. G. Ghobrial, W. C. Mahoney and P. Westermark.

Eventually, however, direct animal experimental work showed unequivocally that circulating SAA is converted into amyloid fibrils [86, 87]. A systemic form of amyloidosis, resembling human secondary amyloidosis, had long been known to occur in many different mammals (for reviews, see [88, 89]), the most well known being that seen in mice. Secondary amyloidosis was also a common outcome in horses which had been immunized for antiserum production. At an early date, it was found to be possible to induce secondary amyloidosis in laboratory animals, including rabbits, hens [90] and mice [91, 92].

Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 1984, 120, 885–890. Glenner, G. G. and C. W. Wong. Alzheimer’s disease and Down’s syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun 1984, 122, 1131–1135. , G. Simms, N. A. Weinman, G. Multhaup, B. L. McDonald and K. Beyreuther. Amyloid plaque core protein in Alzheimer disease and References 147 148 149 150 151 152 153 154 155 156 157 Down syndrome.

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