By Kewal K. Jain
Culling jointly excerpts from a variety of writings by means of Dr. Kewal ok. Jain on biotechnology issues as they relate to issues of the worried procedure, Applications of Biotechnology in Neurology covers numerous functions for these operating in lifestyles sciences and the pharmaceutical sciences, relatively these constructing diagnostics and therapeutics for the anxious procedure. This designated quantity delves into components akin to neurobiotechnology, like neurogenomics and neuroproteomics, molecular diagnostics, quite a few tools of bettering systemic management of substances for designated supply to the worried procedure, together with using nanobiotechnology, biotechnology-based thoughts and items for neuroprotection, in addition to chapters on neurosurgery and customized neurology.
Thorough, state-of-the-art, and thoughtfully prepared, Applications of Biotechnology in Neurology serves as an amazing consultant, supplemented by way of seventy five tables and sixteen figures in addition to a variety of references from contemporary literature in this subject, that are appended to every chapter.
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Additional info for Applications of Biotechnology in Neurology
The phenomenon of prion aggregation may have a wider physiological importance, which is not fully understood. It may involve maintaining neuronal functions and possibly contributing to the establishment of long-term memory (Norrby 2011). Transmissible Spongiform Encephalopathies Transmissible spongiform encephalopathies (TSEs) consist of a group of fatal neurodegenerative diseases in animals and man, which can be transmitted experimentally. The common feature of TSEs is the accumulation of an abnormal isoform of prion protein in the brains of affected animals and humans.
Regulation of gene expression by genetics involves a change in the DNA sequence, whereas epigenetic regulation involves alteration in chromatin structure and methylation of the promoter region. DNA methylation represents an epigenetic means of inheritance without associated DNA sequence alterations. The role of epigenetics in the etiology of human disease is increasingly recognized with the most obvious evidence found for genes subject to genomic imprinting. The study of model organisms often provides the ﬁrst clues to the identity of a genetic defect in human disease.
4 1 Genomics Genetics Introduction to Neurobiotechnology Proteomics RNAi Antisense Metabolomics Gene therapy Neurogenetics Neurogenomics Neuroproteomics Molecular diagnosis Sequencing Biomarkers Synthetic biology NEUROLOGY Molecular imaging Cell therapy Neuropathology Ion channels Monoclonal antibodies Nanobiotechnology Neuropharmacology Fig. 1 Relationships of biotechnologies to neurology (© Jain PharmaBiotech) References Aebischer P, Kato AC. Treatment of amyotrophic lateral sclerosis using a gene therapy approach.