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By Scott A., Prof. Snyder, Marco Bella, Alexander Dömling, Jon Boyce, Gaelle Blond, Iain Coldham

The quick velocity of evolution in domino, or cascade-based changes has revolutionized the perform of chemical synthesis for the production of ordinary items, designed molecules, and pharmaceuticals.


"Science of Synthesis: functions of Domino variations in natural Synthesis" explores the subject completely and systematically, serving because the foundation for functional purposes and destiny study. The 2-volume set provides the state of the art by way of layout, method, and experimental techniques, resulting in a number of occasions being comprehensive inside a unmarried response vessel. The content material is equipped via the middle form of response used to begin the development, be it a pericyclic response, a metal-mediated transformation, radical chemistry, or an acid-induced cascade between many others.


Volume 2 covers pericyclic reactions (Diels-Alder, sigmatropic shifts, ene reactions), dearomatizations, and additions to C-O/C-N a number of bonds.

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Extra resources for Applications of domino transformations in organic synthesis 2

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3 Phosphoric Acid Catalyzed Domino Addition to C=O Bonds . . . . . . . . . 3 Lewis Acid Catalyzed Domino Addition to C=O Bonds . . . . . . . . . . . 4 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Additions to C=N Bonds and Nitriles E. Kroon, T. Zarganes Tzitzikas, C. G. Neochoritis, and A. 4 Additions to C=N Bonds and Nitriles . . . . . . . . . . . . . . . . . . .

4 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Additions to C=N Bonds and Nitriles E. Kroon, T. Zarganes Tzitzikas, C. G. Neochoritis, and A. 4 Additions to C=N Bonds and Nitriles . . . . . . . . . . . . . . . . . . . 1 Addition to C=N Bonds and the Pictet–Spengler Strategy . . . . . . . . . . 2 Ugi Five-Center Four-Component Reaction Followed by Postcondensations . 3 Addition to Nitriles .

The flask was sealed under argon, and the mixture was protected from light and stirred at 45 8C for 4 h. The mixture was filtered through a plug of cotton and concentrated. 6 g (61%). 5 Through Allylation Allylation can be a viable precursor reaction to a Diels–Alder union by virtue of the unsaturation of the resultant product. [35] Treatment of acyclic epoxide 33 with diethylaluminum chloride leads to a cascade sequence wherein a doubly vinylogous Sakurai-type alkenation provides dienyl intermediate 34.

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