Download Biocompatibility and performance of medical devices by Jean-Pierre Boutrand PDF

By Jean-Pierre Boutrand

Implant and machine brands are more and more having to stand the problem of proving that their implants or units are safe/biocompatible and practice as promised. it's also very important that brands can effectively and effectively predict the biocompatibility in their units earlier than they're implanted. The foreign workforce of individuals and editor describe and clarify the criteria that impression the biocompatibility of fabrics and scientific units. Introductory chapters supply an creation to biocompatibility, examine the evaluate and characterization of biocompatibility in clinical units and evaluation checking out and interpretation of scientific equipment performance.  The end explains the histopathological ideas for biocompatibility and function reports.

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Extra resources for Biocompatibility and performance of medical devices

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A similar situation may be seen with biomaterials-based systems in delivering molecular or nanoparticulate agents to cells, either for therapeutic or diagnostic purposes. Examples here include superparamagnetic iron oxide nanoparticle magnetic resonance imaging (MRI) contrast agents, cationic polymers as non-viral gene vectors, carbon nanotubes filled with chemotherapeutic agents and functionalized carriers for immunotherapeutic agents. None of these systems will work if the material carrier or agent is ignored by the target cells; instead they have to be attracted to them or possibly bind to highly specific receptors on cell surfaces.

G. plates and screw made respectively of stainless steel and TiA6V). All orthopedic surgeons have documented examples with corrosion pictures, associated with surrounding tissue discoloring or even necrosis. Systemic increase in the level of released metallic ions may create mutagenicity or clastogenicity concerns. The mechanical resistance of the device is impaired through the corrosion process, even leading to implant rupture. In these examples, the intrinsic biocompatibility of each component is established according to conformity to specifications for implantable materials, but the clinical conditions of use create additional features that will impact the toxicological profile as well as the final performance of each device.

Controlling factors: Although biocompatibility is obviously controlled by the nature of the material, device or agent, it is clearly influenced by many © Woodhead Publishing Limited, 2012 Concepts in biocompatibility 11 other factors. Biocompatibility phenomena vary from patient to patient, and with the techniques used to administer the biomaterial to the patient. Biocompatibility is therefore a series of individual phenomena that combine to generate the overall host response. Since there are so many variables that may affect each of these components and the mechanisms that are associated with them, it should not be surprising that there are an almost infinite number of possible features of the host response.

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