Download Biomanufacturing by Homare Tabata (auth.), Jian-Jiang Zhong (eds.) PDF

By Homare Tabata (auth.), Jian-Jiang Zhong (eds.)

Advances in bioproducts production corresponding to the construction of the anticancer drug paclitaxel by way of large-scale plant telephone tradition, submerged cultivation of medicinal mushrooms, and monoclonal antibody creation are mirrored. Interactions between molecular, mobile and strategy engineering facets in commercial fermentations are mentioned, and alertness of fuzzy keep an eye on and fuzzy neural networks to useful construction and the biomedical region are proven. For sustainable improvement and eco-friendly processing, creation of lactic acid from paper sludge, creation of a frequent fermentation feedstock from wheat, and fabrication and alertness of whole-cell dependent biosensors within the atmosphere also are demonstrated.

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J. Zhong · Y-J. 3 Scale-up of submerged cultures . . . . Scale-up of liquid static cultures . . . . Effect of initial KLa . . . . . . . . Effect of liquid surface area per liquid volume Cultivation in static bioreactors . . . . Process modeling . . . . . . . . Parameter estimation . . . . . . . Parameter sensitivity analysis . . . . . Model validation . . . . . . . . 7 Conclusions 8 References . . . . . . . . . . . . . . . . . .

7 Conclusions 8 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44 46 47 49 51 52 54 54 55 . . . . . . . . . . . . . . . 57 . . . . . . . . . . . . . . . . 58 1 Introduction The number of types of mushroom on Earth is estimated at 140,000, yet maybe only 10% (approximately 14,000 named species) are known, of which 2000 are estimated to be edible; few have been studied thoroughly from the standpoint of their commercial potential.

Two-stage cultivation . . . . . . . . . . 6 Process scale-up and modeling . . . . . . . . . . 44 . . . 35 . . . 36 . . . 38 . . . 39 . . . -J. Zhong · Y-J. 3 Scale-up of submerged cultures . . . . Scale-up of liquid static cultures . . . . Effect of initial KLa . . . . . . . . Effect of liquid surface area per liquid volume Cultivation in static bioreactors . . . . Process modeling . . . . . . . . Parameter estimation . . . . .

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