Download Biotechnology in Growth Regulation by R.B. Heap, C.G. Prosser and G.E. Lamming (Eds.) PDF

By R.B. Heap, C.G. Prosser and G.E. Lamming (Eds.)

This ebook seems to be on the use of development hormones in animal creation. It offers with the topic on numerous degrees, from the connection of the expansion hormone to similar proteins, to the particular insertion of progress genes into animal embryos

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Underwood. E.. Maes, M . and Ketelslegers. J. M . ( 1988). Acutedownregulation of the somatogenic receptors in rat liver by a single injection of growth hormone. Endocrinology 122, 1291-1296. 30 Posner. B . I . , Patel. B.. Vezinhet, A . and Charrier. J. (1980). Pituitarydependent growth hormone receptors in rabbit and sheep liver. Endocrinology 10/, 1954-1958. 31 Roupas. P. and Herington. A . C . (1986). Growth hormone receptors in cultured adipocytes: a model to study receptor regulation. Molecular and Cellular Endocrinology 47, 81-90.

Using anti-receptor antisera. GH receptors could be demonstrated in neonatal rabbit chondrocytes in the region of the secondary ossification centres although they were not detectable in the growth plate itself until somewhat later (4). Conversely in man where hepatic binding is demonstrable before birth. hGH does not bind to skeletal muscle from fetal tissues (22). E N D O C R I N E A N D M E T A B O L I C R E G U L A T I O N OF T H E G H R E C E P T O R Growth hormone There is considerable evidence that chronic exposure to GH increases the number of GH binding sites in the liver and in adipose tissue.

1). It stimulates general body growth through the mediation largely of IGF-I which is produced mainly by the liver under the direct influence of GH. However. IGF-I, and probably several other growth factors, also play important paracrine roles in the control of the growth and function of many tissues. These locally produced growth mediators may also be. to some extent, under the control of G H . GH also plays an important role in metabolism, stimulating lipolysis. increased production of non-estenfied and free fatty acids and the production of ketones.

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