By David Aminoff
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Extra info for Blood and Tissue Antigens. International Symposium on Blood and Tissue Antigens Held At the University of Michigan Medical Center, September 17-19, 1969
One of the best clues to how the human polymorphisms are involved in survival and reproduction comes from the study of the depression in these indices which can be observed in consanguineous marriages. In man, the net depression in survival (including the effect of maternal inbreeding) is in the neighborhood of 1 percent per each percent of F, the coefficient of inbreeding (65). Thus, if we could follow the conceptuses of first cousin marriages from the moment of conception through reproductive life, scoring also for the increased mortality of their children, we would find about a 6 percent impairment by comparison with suitable controls.
2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. B. Ford, Genetics for Medical Students, London: Methuen, 1942. E. Reed, Proc. Conf. on Genetic Polymorphisms and Geographic Variations in Disease, ed. S. Blumberg, Grune and Stratton, 1961. F. Vogel and J. Kruger, Blut 16, 351 (1968). R. Chakarvartti, Humangenetik 5, 1 (1967). H. Muschel, Bact. Β*ν· 30 427 (1966). E. 62 (1969). H. Gershowitz, Records of Am. Soc. of Hum. Gen. Abstract 46 (1963). E. Morton, H. P. Mi, Am.
30 BLOOD AND TISSUE ANTIGENS Sänger: Would you not then expect, Dr. Beckman, that if you put normal cells into the plasma of En(a-) people, they might become affected in various ways? This has been done and the normal cells were unaltered. We have pretty good evidence, from absorption tests, that the En a antigen is not present on platelets and in Helsinki the electrophoretic mobility of platelets from an En(a-) person was found to be normal. But we got rather confusing results with white cells, perhaps because of the poor separation of white and red cells; and independently, the Finnish workers also got inconclusive electrophoretic results with the white cells.