By Anthony R. Means, Paul Greengard, Angus C. Nairn, Shirish Shenolikar
Quantity 30 examines the renowned function of calcium as an intracellular moment messenger. best investigators overview a large choice of stories on how calcium enters and strikes via cells, the way it interacts with its many binding proteins, and the way calcium and its intracellular receptor, calmodulin, keep watch over very important mobile techniques. insurance contains a exact research of the mechanisms in which calcium absolute to calmodulin regulates contractile proteins in tender muscle cells. shut consciousness is given to the jobs of calcium and calmodulin-dependent protein kinases and phosphatases in synaptic sign transduction, protein synthesis, gene expression, programmed mobilephone demise, activation of T-lymphocytes, and regulate of mobilephone department cycles. different chapters talk about experiences utilizing genetically manipulable nonmammalian organisms to extra proble the services of calcium and calmodulin.
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Additional resources for Calcium Regulation of Cellular Function, Volume 30 (Advances in Second Messenger & Phosphoprotein Research)
Rose et al. , two closed states, one open state, and gradual entry into an absorbing inactivating state [see Fig. 2A]). However, this model failed in that it could not be adequately constrained to simultaneously describe both the peak and the later maintained pedestal. Further analysis revealed three distinct patterns of L-channel gating: (a) blanks, (b) records with activity concentrated at the beginning of depolarizations ("active early"), and (c) records with more activity occurring later in the pulse ("active late").
Annu Rev Biophys Chem 1991;20:153-174. INTRA CELLULAR CALCIUM WAVES 23 42. Lechleiter JL, Clapham DE. Molecular mechanisms of intraceUular calcium release in Xenopus laevis oocytes. Cell 1992;69:283-294. 43. Boitano S, Dirksen ER, Sanderson MJ. Intercellular propagation of calcium waves mediated by inositol trisphosphate. Science 1992;258:292-295. 44. Charles A, Merrill JE, Dirksen ER, Sanderson MJ. Intercellular signalling in glial cells: calcium waves and oscillations in response to mechanical stimulation and glutamate.
Bezprozvanny I, Watras J, Ehrlich BE. Bell-shaped calcium-response curves of Ins(1,4,5)P3and calcium-grated channels from endoplasmic reticulum of cerebellum. Nature 1991;351:751754. 54. Finch EA, Turner TJ, Goldin SM. Calcium as a coagonist of inositol 1,4,5-trisphosphate-induced calcium release. Science 1991;252:442-446. 55. Iino M, Endo M. Calcium-dependent immediate feedback control of inositol 1,4,5-trisphosphateinduced Ca 2+ release. Nature 1992;360:76-78. 56. Parker I, Ivorra I. Inhibition by Ca 2§ of inositol trisphosphate-mediated Ca 2 § liberation: a possible mechanism for oscillatory release of Ca2§ Proc Natl Acad Sci USA 1990;87:260-264.