By Jesus Jimenez-Barbero, F. Javier Canada, Sonsoles Martin-Santamaria (eds.)
In fresh years there was expanding proof of the significance of carbohydrates and glycoconjugates in biomedical functions, and using man made ligands in keeping with carbohydrates as medicinal drugs has obtained a lot recognition. Focussing on drug discovery from key ambitions and putting an emphasis at the multi-disciplinary methods essential to problem those matters, this ebook comprehensively covers the recent and up to date discoveries within the sector of carbohydrate drug discovery.
Carbohydrates in Drug layout and Discovery is divided into 5 sections, starting with a creation and point of view at the present marketplace. The publication then is going directly to speak about new artificial equipment in glycobiology, using glycobiology in chemical biology and glycobiology in drug discovery.
Providing a global viewpoint in this vast region, and offering examples of therapeutics already built utilizing those equipment, this e-book presents a accomplished creation, dialogue and replace in this quick constructing box for medicinal chemists and biochemists operating in and academia.
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Haselhorst, J. M. Garcia, T. Islam, J. C. Lai, F. J. Rose, J. M. Nicholls, J. S. Peiris and M. von Itzstein, Angew. , Int. , 2008, 47, 1910–1912. 25. C. Rademacher, N. R. Krishna, M. Palcic, F. Parra and T. Peters, J. Am. Chem. , 2008, 130, 11. 36 Chapter 2 26. (a) B. Fiege, C. Rademacher, J. Cartmell, P. I. Kitov, F. Parra and T. Peters, Angew. , Int. , 2012, 51, 928–932; (b) C. Rademacher, J. Guiard, P. I. Kitov, B. Fiege, K. P. Dalton, F. Parra, D. R. Bundle and T. Peters, Chem. – Eur. , 2011, 17, 7442–7453.
A) B. Meyer and T. Peters, Angew. , Int. , 2003, 42, 864–890; (b) A. C. Lepre, M. J. Moore and W. J. Peng, Chem. , 2004, 104, 3641–3675; (c) J. Angulo and P. M. Nieto, Eur. Biophys. , 2011, 40, 1357–1369; (d) L. P. Calle, F. J. Canada and J. Jimenez-Barbero, Nat. Prod. , 2011, 28, 1118–1125; (e) M. A. Johnson and B. M. Pinto, Carbohydr. , 2004, 339, 907–928; (f) A. Bhunia, S. Bhattacharjya and S. Chetterjee, Drug Discovery Today, 2012; (g) T. Carlomagno, Annu. Rev. Biophys. Biomol. , 2005, 34, 245–66; (h) J.
Ojeda, P. M. Nieto, 6. A. Canales, R. Lozano, B. , M. Martı G. Gimenez-Gallego and J. Jime 2006, 273, 4716. 7. M. Mayer and B. Meyer, Angew. , Int. , 1999, 38, 1784. 8. M. Vogtherr and T. Peters, J. Am. Chem. , 2000, 122, 6093–6099. 9. A. Silipo, J. Larsbrink, R. Marchetti, R. Lanzetta, H. Brumer and A. Molinaro, Chem. – Eur. , 2012, 18, 13395. ˜ ada, S. Andre ´, J. Jime ´nez-Barbero and 10. T. Diercks, J. P. Ribeiro, F. J. -J. Gabius, Chem. – Eur. , 2009, 15, 5666. ´mez, F. J. Can ˜ada, A. L. Corbı´ and J.